作者
Meagan P O’Brien, Eduardo Forleo-Neto, Neena Sarkar, Flonza Isa, Peijie Hou, Kuo-Chen Chan, Bret J Musser, Katharine J Bar, Ruanne V Barnabas, Dan H Barouch, Myron S Cohen, Christopher B Hurt, Dale R Burwen, Mary A Marovich, Elizabeth R Brown, Ingeborg Heirman, John D Davis, Kenneth C Turner, Divya Ramesh, Adnan Mahmood, Andrea T Hooper, Jennifer D Hamilton, Yunji Kim, Lisa A Purcell, Alina Baum, Christos A Kyratsous, James Krainson, Richard Perez-Perez, Rizwana Mohseni, Bari Kowal, A Thomas DiCioccio, Gregory P Geba, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D Yancopoulos, David M Weinreich, Neal Warshoff, Liudmila Moreiras, Dario Altamirano, Dickson Ellington, Faisal Faikih, William Smith, Richard Gibson, Katie Buckner, Robert Rosen, Amy Sapp, Anita Kohli, Vicki McIntyre, Yessica Sachdeva, Amanda McFarland, Dina Gibson, Kenneth Kim, Jason Ahn, Lisa Neinchel, Nayna Paryani, Amber Mottola, Eva Day, Martha Navarro, Rafaelito Victoria, Xanthe Victoria, Rene Uong, Mindy Sampson, Christopher Polk, Michael Leonard, Lewis McCurdy, Leigh A Medaris, Zainab Shahid, Lisa Davidson, Jawad Nazir, John Lee, Amy Elliott, Swami Sathyanaryan, Mansi Oberoi, Muhammad Danial Siddiqui, Muhammad Arsad, Kara Bruning, Sybil Hosek, Temitope Oyedele, Vanessa Sarda, Monica Mercon, Kathryn Stephenson, Boris Juelg, Chen Sabrina Tan, Rebecca Zash, Ai-ris Collier, Jessica Ansel, Kate Jaegle, Lilia Roque-Guerrero, Ana Gomez Ramirez, Javier Capote, Gisel Paz, Michael Paasche-Orlow, Julien Dedier, Sanjay Vadgama, Ramachandra Patak, Nicolas Chronos, Cary Hefty, Judith Borger, Ifeanyi Momodu, Lindsey Carswell, Benjamin King, Ryan Starr, Scott Syndergaard, Nancy Patel, Ravikumar Patel, Ryan Sattar, Jeffrey Unger, Sheila De Jesus-Maranan, Cecilia Casaclang, Michael Seep, Celeste Brown, Joshua Whatley, Dennis Levinson, Saad Alvi, Norman James, Azazuddin Ahmed, Robinson Koilpillai, Stephanie Cassady, Jennifer Cox, Eduardo Torres, Mark J Rosenthal, Michael Winnie, Jerry Plemons, Omesh Verma, Richard Leggett, Ramon Reyes, Keith Beck, Brian Poliquin, Murtaza Mussaji, Jignesh Shah, David Sutton, Edward Pereira, Rodel Gloria, Stacey Kelly, Amy Dennis-Saltz, Mae Sheikh-Ali, Elias Saikali, James Magee, Rebecca Goldfaden, Haresh Boghara, Sunny Patel, Bari Eichelbaum, Duane Anderson, Sean Su, Alexander Akhavan, Diana Kirby, Joy Venglik, Kenneth Mayer
发表日期
2022/2/1
期刊
Jama
卷号
327
期号
5
页码范围
432-441
出版商
American Medical Association
简介
Importance
Easy-to-administer anti–SARS-CoV-2 treatments may be used to prevent progression from asymptomatic infection to symptomatic disease and to reduce viral carriage.
Objective
To evaluate the effect of combination subcutaneous casirivimab and imdevimab on progression from early asymptomatic SARS-CoV-2 infection to symptomatic COVID-19.
Design, Setting, and Participants
Randomized, double-blind, placebo-controlled, phase 3 trial of close household contacts of a SARS-CoV-2–infected index case at 112 sites in the US, Romania, and Moldova enrolled July 13, 2020–January 28, 2021; follow-up ended March 11, 2021. Asymptomatic individuals (aged ≥12 years) were eligible if identified within 96 hours of index case positive test collection. Results from 314 individuals positive on SARS-CoV-2 reverse transcriptase–quantitative polymerase chain reaction (RT-qPCR) testing are reported …
学术搜索中的文章
MP O'Brien, E Forleo-Neto, N Sarkar, F Isa, P Hou… - Jama, 2022