作者
Jenny L Donovan, Freddie C Hamdy, J Athene Lane, Malcolm Mason, Chris Metcalfe, Eleanor Walsh, Jane M Blazeby, Tim J Peters, Peter Holding, Susan Bonnington, Teresa Lennon, Lynne Bradshaw, Deborah Cooper, Phillipa Herbert, Joanne Howson, Amanda Jones, Norma Lyons, Elizabeth Salter, Pauline Thompson, Sarah Tidball, Jan Blaikie, Catherine Gray, Prasad Bollina, James Catto, Andrew Doble, Alan Doherty, David Gillatt, Roger Kockelbergh, Howard Kynaston, Alan Paul, Philip Powell, Stephen Prescott, Derek J Rosario, Edward Rowe, Michael Davis, Emma L Turner, Richard M Martin, David E Neal
发表日期
2016/10/13
期刊
New England Journal of Medicine
卷号
375
期号
15
页码范围
1425-1437
出版商
Massachusetts Medical Society
简介
Background
Robust data on patient-reported outcome measures comparing treatments for clinically localized prostate cancer are lacking. We investigated the effects of active monitoring, radical prostatectomy, and radical radiotherapy with hormones on patient-reported outcomes.
Methods
We compared patient-reported outcomes among 1643 men in the Prostate Testing for Cancer and Treatment (ProtecT) trial who completed questionnaires before diagnosis, at 6 and 12 months after randomization, and annually thereafter. Patients completed validated measures that assessed urinary, bowel, and sexual function and specific effects on quality of life, anxiety and depression, and general health. Cancer-related quality of life was assessed at 5 years. Complete 6-year data were analyzed according to the intention-to-treat principle.
Results
The rate of questionnaire completion during follow-up was higher than 85% for …
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JL Donovan, FC Hamdy, JA Lane, M Mason… - New England Journal of Medicine, 2016