作者
Rachel B Jimenez, Soha Ahmed, Andrew Johnson, Horatio Thomas, Nicolas Depauw, Nora Horick, Joanna Tansky, Casey L Evans, Margaret Pulsifer, David Ebb, William E Butler, Barbara Fullerton, Nancy J Tarbell, Torunn I Yock, Shannon M MacDonald
发表日期
2021/8/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
110
期号
5
页码范围
1480-1487
出版商
Elsevier
简介
Background
Radiation therapy (RT) is used for pediatric craniopharyngioma in the definitive, adjuvant, or salvage settings. Proton RT may be useful owing to tumor proximity to eloquent anatomy. We report clinical outcomes for a large cohort treated with proton therapy.
Methods
We conducted a retrospective review of pediatric patients (≤21 years) treated with surgery and proton therapy for craniopharyngioma between August 2002 and October 2018. Clinical characteristics, treatment course, and outcomes were recorded. Acute toxicity was graded using Common Terminology Criteria for Adverse Events, version 5.0. Late toxicity was assessed using neuroendocrine, neuro-ophthalmologic, and neuropsychological testing.
Results
Among 77 patients, median age at diagnosis was 8.6 years (range, 1.3-20); median age at radiation was 9.6 years (range, 2.3-20.5). Most common presenting symptoms were headache (58 …
学术搜索中的文章
RB Jimenez, S Ahmed, A Johnson, H Thomas… - International Journal of Radiation Oncology* Biology …, 2021