作者
Kristy R Howell, Jennifer Armstrong
发表日期
2017/12
来源
Current Behavioral Neuroscience Reports
卷号
4
页码范围
299-308
出版商
Springer International Publishing
简介
Purpose of the Review
Neurovascular dysfunction and the role of vascular endothelial growth factor (VEGF) have been explored in neurodevelopmental disorders including schizophrenia, bipolar disorder, major depressive and mood disorders, and autism. These disorders are correlated with hypoxia-ischemia insults during early life and are strongly associated with cognitive dysfunction. This review focuses on the hypoxia-regulated protein, VEGF, to discuss its crucial roles in brain development and function. These data implicate that alterations to VEGF signaling during early life can impair neural development, underlying the severe cognitive deficits observed in neurodevelopmental disorders.
Recent Findings
VEGF has been linked to neurological processes that influence learning and memory. VEGF is advancing towards being a novel biomarker and …
学术搜索中的文章
KR Howell, J Armstrong - Current Behavioral Neuroscience Reports, 2017