作者
Aakriti Gupta, Mahesh V Madhavan, Kartik Sehgal, Nandini Nair, Shiwani Mahajan, Tejasav S Sehrawat, Behnood Bikdeli, Neha Ahluwalia, John C Ausiello, Elaine Y Wan, Daniel E Freedberg, Ajay J Kirtane, Sahil A Parikh, Mathew S Maurer, Anna S Nordvig, Domenico Accili, Joan M Bathon, Sumit Mohan, Kenneth A Bauer, Martin B Leon, Harlan M Krumholz, Nir Uriel, Mandeep R Mehra, Mitchell SV Elkind, Gregg W Stone, Allan Schwartz, David D Ho, John P Bilezikian, Donald W Landry
发表日期
2020/7
来源
Nature medicine
卷号
26
期号
7
页码范围
1017-1032
出版商
Nature Publishing Group US
简介
Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Here we review the extrapulmonary organ-specific pathophysiology, presentations …
学术搜索中的文章
A Gupta, MV Madhavan, K Sehgal, N Nair, S Mahajan… - Nature medicine, 2020