作者
Reza Yazdani, Robabeh Seify, Mazdak Ganjalikhani-Hakemi, H Abolhassani, Nahid Eskandari, F Golsaz-Shirazi, B Ansaripour, E Salehi, Gholamreza Azizi, Nima Rezaei, A Aghamohammadi
发表日期
2017/3/1
期刊
Allergologia et immunopathologia
卷号
45
期号
2
页码范围
183-192
出版商
No longer published by Elsevier
简介
Background
Common variable immunodeficiency (CVID) is a heterogeneous disease, characterised by hypogammaglobulinaemia leading to recurrent infections and various complications. The aim of this study was to classify CVID patients based on four known classifications (Paris, Freiburg, EUROclass, and B-cell patterns) by measurement of B-cell subsets and to assess the relation of each classification with clinical manifestations.
Methods
We measured all B-cell subsets as both absolute count and percentage in 30 CVID patients and 30 healthy individuals using four-colour flow cytometry. Moreover, we evaluated antibody responses to pneumococcal vaccine in patients.
Results
A significant reduction in percentage of terminal B-cell subsets (total, marginal zone-like, switched memory, IgM-only memory, total memory B-cells and plasmablast) and absolute count of all B-cell subsets along with a strong increase in …
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R Yazdani, R Seify, M Ganjalikhani-Hakemi… - Allergologia et immunopathologia, 2017