作者
Reza Yazdani, Maryam Fatholahi, Mazdak Ganjalikhani-Hakemi, Hassan Abolhassani, Gholamreza Azizi, Kabir Magaji Hamid, Nima Rezaei, Asghar Aghamohammadi
发表日期
2016/3/1
来源
Molecular immunology
卷号
71
页码范围
1-9
出版商
Pergamon
简介
Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibody production, decreased lymphocyte proliferation and defective cytokine secretion. For the first time, we reviewed the role of apoptosis in CVID and SIgAD.
学术搜索中的文章
R Yazdani, M Fatholahi, M Ganjalikhani-Hakemi… - Molecular immunology, 2016