作者
Hee-Yeon Jung, Su-Hee Kim, Min-Young Seo, Sun-Young Cho, Youngae Yang, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Dong Il Won, Chan-Duck Kim
发表日期
2018/8/8
期刊
Journal of Korean Medical Science
卷号
33
期号
34
出版商
Korean Academy of Medical Sciences
简介
Background
The association of de novo donor-specific anti-human leukocyte antigens (HLA) antibodies (DSA) and development of antibody-mediated rejection (AMR) in kidney transplant recipients (KTRs) is still undetermined.
Methods
We prospectively screened de novo DSA in 167 KTRs during 32 months after kidney transplantation (KT). Timing of DSA detection was at 3, 6, and 12 months post-transplant and annually thereafter and when clinically indicated. DSA levels were determined by Luminex assays and expressed as mean fluorescence intensity (MFI). We evaluated the incidence, characteristics of DSA, and association between DSA and tacrolimus trough levels or AMR.
Results
De novo DSA developed in 16 KTRs (9.6%) and acute AMR occurred more commonly in KTRs with de novo DSA compared to KTRs without de novo DSA (18.8% vs. 0%, P< 0.001). All de novo DSA were against class II antigens …
学术搜索中的文章
HY Jung, SH Kim, MY Seo, SY Cho, Y Yang, JY Choi… - Journal of Korean Medical Science, 2018