作者
VA Tyurin, Krishnakumar Balasubramanian, Daniel Winnica, YY Tyurina, AS Vikulina, RR He, AA Kapralov, CH Macphee, VE Kagan
发表日期
2014/5
期刊
Cell Death & Differentiation
卷号
21
期号
5
页码范围
825-835
出版商
Nature Publishing Group
简介
Diversified anionic phospholipids, phosphatidylserines (PS), externalized to the surface of apoptotic cells are universal phagocytic signals. However, the role of major PS metabolites, such as peroxidized species of PS (PSox) and lyso-PS, in the clearance of apoptotic cells has not been rigorously evaluated. Here, we demonstrate that H 2 O 2 was equally effective in inducing apoptosis and externalization of PS in naive HL60 cells and in cells enriched with oxidizable polyunsaturated species of PS (supplemented with linoleic acid (LA)). Despite this, the uptake of LA-supplemented cells by RAW264. 7 and THP-1 macrophages was more than an order of magnitude more effective than that of naive cells. A similar stimulation of phagocytosis was observed with LA-enriched HL60 cells and Jurkat cells triggered to apoptosis with staurosporine. This was due to the presence of PSox on the surface of apoptotic LA …
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VA Tyurin, K Balasubramanian, D Winnica, YY Tyurina… - Cell Death & Differentiation, 2014