作者
Alexandra van Dissel, Alexander Opotowsky, Jamil A Aboulhosn, Martijn Kauling, Salil Ginde, Eric Krieger, Sangeeta Shah, Tripti Gupta, Fred Rodriguez, Anitha John, Sandra Jaidzeka, Timothy Cotts, Mary Stumpf, Cindy Dwight, Patty Woods, Jeremy Nicolarsen, Berardo Sarubbi, Flavia Fusco, Petra Antonova, Susan M Fernandes, Jasmine Grewal, Mikyla Janzen, Jonathan CRAMER, Paul Khairy, Pastora Gallego, Clare O’Donnell, Jane Hannah, Mikael G Dellborg, Isabelle Vonder Muhll, Stephen Pylypchuk, Anthony Magalski, Christopher DeZorzi, Frank Han, Amanda Sammons, Joseph Kay, elizabeth yeung, David Baker, David Celermajer, Luke Burchill, Craig Broberg
发表日期
2020/11/17
期刊
Circulation
卷号
142
期号
Suppl_3
页码范围
A16329-A16329
出版商
Lippincott Williams & Wilkins
简介
Background: Occasionally patients with congenitally corrected transposition of the great arteries (ccTGA) exhibit little clinical evidence of cardiovascular limitation even to their 8th decade. We aimed to assess survival prospects in a large cohort of ccTGA adults.
Methods & Results: We included 555 ccTGA adults (median age 33.0 years, 48.3% female) under regular follow-up at 28 institutions between 2002 and 2019. The primary outcome was a composite of death, mechanical circulatory support (MCS) and heart transplant. During a median follow-up of 8.1 [IQR 4.4 - 13.3] years, 56 (10.1%) patients died, 10 (1.8%) patients underwent MCS and 14 (2.5%) had a heart transplant. Median age at time of primary outcome was 51.1 [IQR 37.5 - 63.2] years and cumulative incidence at 15 years from baseline was 21.5% [95% CI 16.1 - 26.5]. Leading causes of death were worsening of heart failure (43%) and sudden death …
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A van Dissel, A Opotowsky, JA Aboulhosn, M Kauling… - Circulation, 2020