作者
Mario Tumbarello, Enrico Maria Trecarichi, Francesco Giuseppe De Rosa, Maddalena Giannella, Daniele Roberto Giacobbe, Matteo Bassetti, Angela Raffaella Losito, Michele Bartoletti, Valerio Del Bono, Silvia Corcione, Giuseppe Maiuro, Sara Tedeschi, Luigi Celani, Chiara Simona Cardellino, Teresa Spanu, Anna Marchese, Simone Ambretti, Roberto Cauda, Claudio Viscoli, Pierluigi Viale, ISGRI-SITA (Italian Study Group on Resistant Infections of the Società Italiana Terapia Antinfettiva)
发表日期
2015/7
期刊
Journal of Antimicrobial Chemotherapy
卷号
70
期号
7
页码范围
2133-2143
出版商
Oxford University Press
简介
Objectives
Infections caused by Klebsiella pneumoniae (Kp) carbapenemase (KPC)-producing strains of Kp have become a significant threat in recent years. To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010–13) retrospective cohort study in five large Italian teaching hospitals.
Methods
The cohort included 661 adults with bloodstream infections (BSIs; n = 447) or non-bacteraemic infections (lower respiratory tract, intra-abdominal structure, urinary tract or other sites) caused by a KPC-Kp isolate. All had received ≥48 h of therapy (empirical and/or non-empirical) with at least one drug to which the isolate was susceptible.
Results
Most deaths occurred within 2 weeks of infection onset (14 day mortality: 225/661, 34.1%). Logistic regression analysis identified BSI (OR, 2.09; 95% CI, 1.34–3.29), presentation …
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M Tumbarello, EM Trecarichi, FG De Rosa… - Journal of Antimicrobial Chemotherapy, 2015