作者
Daniela Cardinale, Fabio Ciceri, Roberto Latini, Maria Grazia Franzosi, Maria Teresa Sandri, Maurizio Civelli, GianFranco Cucchi, Elisabetta Menatti, Maurizio Mangiavacchi, Raffaele Cavina, Enrico Barbieri, Stefania Gori, Alessandro Colombo, Giuseppe Curigliano, Michela Salvatici, Antonio Rizzo, Francesco Ghisoni, Alessandra Bianchi, Cristina Falci, Michele Aquilina, Andrea Rocca, Anna Monopoli, Carlo Milandri, Giuseppe Rossetti, Marco Bregni, Marco Sicuro, Alessandra Malossi, Daniele Nassiacos, Claudio Verusio, Monica Giordano, Lidia Staszewsky, Simona Barlera, Enrico B Nicolis, Michela Magnoli, Serge Masson, Carlo M Cipolla, CM Cipolla, D Cardinale, F Ciceri, R Latini, MT Sandri, AP Maggioni, R Labianca, M Tettamanti, M Senni, A Finzi, F Grosso, T Vago, M Civelli, S Gramenzi, S Masson, G Balconi, R Bernasconi, M Salvatici, E Nicolis, S Barlera, M Magnoli, MG Buratti, ML Ojeda Fernandez, MG Franzosi, L Staszewsky, A Vasamì, A Malossi, M Sicuro, B Thiebat, C Barè, A Corzani, F Coccolo, S Colecchia, C Pellegrini, M Bregni, L Appio, I Caico, G Rossetti, O Mesenzani, C Campana, M Giordano, M Gilardoni, G Scognamiglio, G Corrado, D Battagin, F De Rosa, C Carpino, S Palazzo, A Monopoli, C Milandri, PG Giannessi, G Zipoli, F Ghisoni, A Rizzo, P Pastori, S Callegari, C Sesenna, A Colombo, G Curigliano, C Fodor, M Mangiavacchi, R Cavina, D Guiducci, R Mazza, FM Turazza, P Vallerio, L Marbello, E Sala, G Fragasso, S Trinca, M Aquilina, A Rocca, A Farolfi, D Andreis, S Gori, E Barbieri, L Lanzoni, F Marchetti, C Falci, A Bianchi, E Mioranza, A Banzato, F Re, N Gaibazzi, M Gullo, MC Turina, E Gervasi, F Giaroli, D Nassiacos, C Verusio, B Barco, A Bertolini, G Cucchi, E Menatti, G Sinagra, A Aleksova, A Guglielmi, G Pinotti, R Gueli, C Mongiardi, I Vallini
发表日期
2018/5/1
期刊
European journal of cancer
卷号
94
页码范围
126-137
出版商
Pergamon
简介
Background
Troponin changes over time have been suggested to allow for an early diagnosis of cardiac injury ensuing cancer chemotherapy; cancer patients with troponin elevation may benefit of therapy with enalapril. It is unknown whether a preventive treatment with enalapril may further increase the benefit.
Methods
The International CardioOncology Society-one trial (ICOS-ONE) was a controlled, open-label trial conducted in 21 Italian hospitals. Patients were randomly assigned to two strategies: enalapril in all patients started before chemotherapy (CT; ‘prevention’ arm), and enalapril started only in patients with an increase in troponin during or after CT (‘troponin-triggered’ arm). Troponin was assayed locally in 2596 blood samples, before and after each anthracycline-containing CT cycle and at each study visit; electrocardiogram and echocardiogram were done at baseline, and at 1, 3, 6 and 12-month follow-up …
学术搜索中的文章
D Cardinale, F Ciceri, R Latini, MG Franzosi, MT Sandri… - European journal of cancer, 2018