作者
Peter Aaby, Christine Benn, Jens Nielsen, Ida Maria Lisse, Amabelia Rodrigues, Henrik Ravn
发表日期
2012/1/1
期刊
BMJ open
卷号
2
期号
3
页码范围
e000707
出版商
British Medical Journal Publishing Group
简介
Background
Measles vaccines (MV) have sex-differential effects on mortality not explained by protection against measles infection.
Objective
The authors examined whether whole-cell diphtheria–tetanus–pertussis (DTP) vaccine has sex-differential and non-specific effects.
Data sources and eligibility
Following previous reviews and a new search, the effect of DTP on mortality up to the next vaccination was assessed in all studies where DTP was given after BCG or DTP was given after MV and there was prospective follow-up after ascertainment of vaccination status.
Setting
High-mortality countries in Africa and Asia.
Methods
The initial observation of negative effect of DTP generated six hypotheses, which were examined in all available studies and two randomised trials reducing the time of exposure to DTP.
Main outcome
Consistency between studies.
Results
In the first study, DTP had negative effects on survival in …
学术搜索中的文章
P Aaby, C Benn, J Nielsen, IM Lisse, A Rodrigues… - BMJ open, 2012
