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Psychological morbidity is common in chronic respiratory diseases. The diagnostic accuracy of the Hospital Anxiety and Depression Scale (HADS) and risk factors for comorbid depression in chronic obstructive pulmonary disease (COPD) are addressed. Consecutive COPD patients (GOLD stage I–IV, 40–75 years old) were enrolled in a multicentre, cross‐sectional cohort study. Diagnosis of depression was ascertained through clinical records. Lung function, HADS score, 6‐minute walking test (6‐MWT), MRC dyspnoea score, and COPD Assessment Test (CAT) were evaluated. Two hundred fifty‐nine COPD patients (mean age 62.5 years; 32% female; mean FEV1 48% predicted) were included. Patients diagnosed with depression (29/259; 11.2%) had significantly higher HADS‐D and HADS‐Total scores than nondepressed patients (median (quartiles) HADS‐D 6 [4; 9] versus 4 [2; 7], median HADS‐Total 14 [10; 20 …