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Sensorimotor gating mechanisms regulate the integration of sensory information in decision-making motor systems. These effects can be quantified in pre-pulse inhibition (PPI) paradigms, wherein weak (subthreshold prepulse) stimuli are used to modify the response to subsequent strong (suprathreshold pulse) stimuli presented short (20-1000 ms) intervals apart. Importantly, although PPI can be activated by visual and/or auditory prepulse stimuli, the mechanisms that integrate multiple afferent modalities are largely unknown. Here, we applied multi-modal PPI paradigms to study the integration of visual and auditory sensory modalities in the startle behavior of goldfish, and recorded soma-dendritic integration in the decision-making neuron (Mauthner cell) that triggers the behavior. Preliminary results indicate two main effects. First, the sequential order of stimulus modalities determines the sensorimotor gating …