作者
Axel Bauer, Mathias Klemm, Konstantinos D Rizas, Wolfgang Hamm, Lukas von Stülpnagel, Michael Dommasch, Alexander Steger, Andrezej Lubinski, Panagiota Flevari, Markus Harden, Tim Friede, Stefan Kääb, Bela Merkely, Christian Sticherling, Rik Willems, Heikki Huikuri, Marek Malik, Georg Schmidt, Markus Zabel, Béla Merkely, Peter Perge, Zoltan Sallo, Gabor Szeplaki, Lars Lüthje, Simon Schlögl, Helge Haarmann, Leonard Bergau, Joachim Seegers, Gerd Hasenfuß, Pascal Munoz-Exposito, Tobias Tichelbäcker, Aleksandra Kirova, Katerina Hnatkova, Marc Vos, Stefan N Willich, Thomas Reinhold, Bert Vandenberk, Magdalena Klinika, Krapinske Toplice, Panayota Flevari, Andreas Katsimardos, Dimitrios Katsaras, Robert Hatala, Martin Svetlosak, Andrzej Lubinski, Tomasz Kuczejko, Jim Hansen, David Conen, Sestre Milosrdnice, Nikola Pavlović, Šime Manola, Ozren Vinter, Ivica Benko, Anton Tuinenburg, Christine Meyer-Zürn, Christian Eick, Jesper Hastrup, Josep Brugada, Elena Arbelo, Gabriela Kaliska, Jozef Martinek, Moritz F Sinner, Konstantinos D Rizas, Nikolay Vdovin, Iwona Cygankiewicz, Pawel Ptaszynski, Krzysztof Kaczmarek, Izabela Poddebska, Svetoslav Iovev, Tomáš Novotný, Milan Kozak, Tuomas Kenttä, Ari Pelli, Jaroslaw D Kasprzak, Dariusz Qavoq, Sandro Brusich, Ervin Avdovic, Marina Klasan, Jan Galuszka, Milos Taborsky, Vasil Velchev, Rüdiger Dissmann, Przemysław Guzik, Dieter Bimmel, Christiane Lieberz, Stefan Stefanow, Norman Rüb, Christian Wolpert, Lars S Maier, Steffen Behrens, Zrinka Jurisic, Frieder Braunschweig, Florian Blaschke, Burkert Pieske, Zoran Bakotic, Ante Anic, Robert HG Schwinger, Pyotr Platonov
发表日期
2019/10/12
期刊
The Lancet
卷号
394
期号
10206
页码范围
1344-1351
出版商
Elsevier
简介
Background
A small proportion of patients undergoing primary prophylactic implantation of implantable cardioverter defibrillators (ICDs) experiences malignant arrhythmias. We postulated that periodic repolarisation dynamics, a novel marker of sympathetic-activity-associated repolarisation instability, could be used to identify electrically vulnerable patients who would benefit from prophylactic implantation of ICDs by way of a reduction in mortality.
Methods
We did a prespecified substudy of EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD), a prospective, investigator-initiated, non-randomised, controlled cohort study done at 44 centres in 15 EU countries. Patients aged 18 years or older with ischaemic or non-ischaemic cardiomyopathy and reduced left ventricular ejection fraction (≤35%) were eligible for inclusion if they …
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A Bauer, M Klemm, KD Rizas, W Hamm… - The Lancet, 2019