作者
Safi U Khan, Maninder Singh, Shahul Valavoor, Muhammad U Khan, Ahmad N Lone, Muhammad Zia Khan, Muhammad Shahzeb Khan, Preethi Mani, Samir R Kapadia, Erin D Michos, Gregg W Stone, Ankur Kalra, Deepak L Bhatt
发表日期
2020/10/13
来源
Circulation
卷号
142
期号
15
页码范围
1425-1436
出版商
Lippincott Williams & Wilkins
简介
Background
The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention with drug-eluting stents remains uncertain. We compared short-term (<6-month) DAPT followed by aspirin or P2Y12 inhibitor monotherapy; midterm (6-month) DAPT; 12-month DAPT; and extended-term (>12-month) DAPT after percutaneous coronary intervention with drug-eluting stents.
Methods
Twenty-four randomized, controlled trials were selected using Medline, Embase, Cochrane library, and online databases through September 2019. The coprimary end points were myocardial infarction and major bleeding, which constituted the net clinical benefit. A frequentist network meta-analysis was conducted with a random-effects model.
Results
In 79 073 patients, at a median follow-up of 18 months, extended-term DAPT was associated with a reduced risk of myocardial infarction in comparison with 12 …
学术搜索中的文章
SU Khan, M Singh, S Valavoor, MU Khan, AN Lone… - Circulation, 2020