作者
Haris Riaz, Safi U Khan, Hammad Rahman, Nishant P Shah, Edo Kaluski, A Michael Lincoff, Steven E Nissen
发表日期
2019/3/1
来源
European journal of preventive cardiology
卷号
26
期号
5
页码范围
533-543
出版商
Oxford University Press
简介
Background
The effects of increasing high-density lipoprotein cholesterol on cardiovascular outcomes remain uncertain.
Design
We conducted a meta-analysis to investigate the effects of high-density lipoprotein cholesterol modifiers (niacin, fibrates and cholesteryl ester transfer protein inhibitors) on cardiovascular outcomes.
Methods
Thirty-one randomized controlled trials (154,601 patients) with a follow-up of 6 months or more and a sample size of 100 or more patients were selected using MEDLINE, EMBASE and CENTRAL database (inception January 2018).
Results
High-density lipoprotein cholesterol modifiers had no statistically significant effect on cardiovascular mortality in terms of relative risk (RR) (RR 0.94, 95% confidence interval (CI) 0.89–1.00, P = 0.05, I2 = 13%) or absolute risk (risk difference −0.0001, 95% CI −0 …
学术搜索中的文章
H Riaz, SU Khan, H Rahman, NP Shah, E Kaluski… - European journal of preventive cardiology, 2019