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Objective: To review the literature that provides information to assist in analyzing the role of the foot in acute and chronic lateral ankle injury.

Data Sources: We searched MEDLINE, CINAHL, Institute for Scientific Information's Web of Science, and SPORT Discus from 1965–2005 using the terms lateral, ankle, ligament, injury, risk factors, foot, subtalar joint, talocrural joint, gait analysis, and foot biomechanics.

Data Synthesis: We found substantial information on the incidence and treatment of lateral ankle sprains in sport but very few articles that focused on risk factors associated with these injuries and even less information on the foot as it relates to this condition. Moreover, little information was available regarding the risk factors associated with the development of chronic instability after a lateral ankle sprain. We critically analyzed the foot articulations and the foot's role in the mechanism of injury to assist our clinical …