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Since the beginning of the intentional production of alcoholic beverages more than 10.000 years ago, drinking has become an integral part of human life, but also a major contributor to increased morbidity and mortality. In search of the mechanisms underlying excessive alcohol consumption, the prefrontal cortex has been shown to play a key role in controlling goal-directed actions and inhibition of inappropriate behaviours and appears to be highly vulnerable to the effects of alcohol. Here, we evaluated how different alcohol consumption patterns impact prefrontal neural networks by recording electrophysiological brain activity directly from the surface of the medial prefrontal cortex of rats using a 3D-printed neuroprosthetic interface. In awake animals, we acquired auditory event-related potentials and oscillatory activity related to perceptual processes and higher-order cognitive functioning. Recordings were …