作者
Khawla Al-Kuraya, Hedvika Novotny, Prashant Bavi, Abdul K Siraj, Shahab Uddin, Adnan Ezzat, Nasser Al Sanea, Fouad Al-Dayel, Hadeel Al-Mana, Salwa S Sheikh, Martina Mirlacher, Coya Tapia, Ronald Simon, Guido Sauter, Luigi Terracciano, Luigi Tornillo
发表日期
2007/7/1
期刊
Journal of clinical pathology
卷号
60
期号
7
页码范围
768-772
出版商
BMJ Publishing Group
简介
Aim: Recent studies had suggested substantial molecular differences between tumours from different ethnic groups. In this study, the molecular differences between the incidences of colorectal carcinoma in Saudi and Swiss populations are investigated.
Method: 518 cases of colon cancer tumours (114 from Saudi Arabia and 404 from Switzerland) were analysed in a tissue microarray format. Fluorescence in situ hybridisation (FISH) was used to estimate frequencies of copy number changes of known oncogenes, including HER2, TOPO2A, CCND1, EGFR and C-MYC.
Results: Using FISH, amplifications were mostly low level (gene-to-centromere ratio 2 to 4), which is in contrast with other tumour types with more frequent gene amplifications. The amplifications were particularly frequent for MYC (Saudi 9% and Swiss 14.2%) but unrelated to clinical outcome and pathological information. Remarkably, there …
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K Al-Kuraya, H Novotny, P Bavi, AK Siraj, S Uddin… - Journal of clinical pathology, 2007