作者
Abdul K Siraj, Rong Bu, Sarita Prabhakaran, Prashant Bavi, Shaham Beg, Mohsen Al Hazmi, Maha Al-Rasheed, Khadija Alobaisi, Fouad Al-Dayel, Hadeel AlManea, Nasser Al-Sanea, Shahab Uddin, Khawla S Al-Kuraya
发表日期
2014/12
期刊
Molecular Cancer
卷号
13
页码范围
1-9
出版商
BioMed Central
简介
Background
Recent studies emphasize the role of BRAF as a genetic marker for prediction, prognosis and risk stratification in colorectal cancer. Earlier studies have reported the incidence of BRAF mutations in the range of 5-20% in colorectal carcinomas (CRC) and are predominantly seen in the serrated adenoma-carcinoma pathway characterized by microsatellite instability (MSI-H) and hypermethylation of the MLH1 gene in the setting of the CpG island methylator phenotype (CIMP). Due to the lack of data on the true incidence of BRAF mutations in Saudi Arabia, we sought to analyze the incidence of BRAF mutations in this ethnic group.
Methods
770 CRC cases were analyzed for BRAF and KRAS mutations by direct DNA sequencing.
Results
BRAF gene mutations were seen in 2.5% (19/757) CRC analyzed and …
学术搜索中的文章
AK Siraj, R Bu, S Prabhakaran, P Bavi, S Beg… - Molecular Cancer, 2014