作者
Jesse Elliott, Shannon E Kelly, Adam C Millar, Joan Peterson, Li Chen, Amy Johnston, Ahmed Kotb, Becky Skidmore, Zemin Bai, Muhammad Mamdani, George A Wells
发表日期
2017/11/1
期刊
BMJ open
卷号
7
期号
11
页码范围
e015284
出版商
British Medical Journal Publishing Group
简介
Objective
To assess the relative effects of individual testosterone products among hypogonadal men.
Design
Systematic review and network meta-analysis.
Methods
We searched MEDLINE, Embase, Cochrane CENTRAL, and grey literature (25 May 2017) for randomised-controlled trials (RCTs) and non-randomised studies (NRS) that involved hypogonadal men given testosterone replacement therapy (TRT) for ≥3 months. Comparators were placebo, another TRT, or the same product at a different dose. Outcomes were quality of life, depression, libido, erectile function, activities of daily living and testosterone levels, as well as cardiovascular death, myocardial infarction, stroke, prostate cancer, heart disease, diabetes, serious adverse events, withdrawals due to adverse events and erythrocytosis. RCT data were pooled via meta-analysis and network meta-analysis. Risk of bias was assessed using Cochrane’s risk of …
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J Elliott, SE Kelly, AC Millar, J Peterson, L Chen… - BMJ open, 2017