作者
Emma C Johnson, Celine L St. Pierre, Jacquelyn L Meyers, Fazil Aliev, Vivia V McCutcheon, Dongbing Lai, Danielle M Dick, Alison M Goate, John Kramer, Samuel Kuperman, John I Nurnberger Jr, Marc A Schuckit, Bernice Porjesz, Howard J Edenberg, Kathleen K Bucholz, Arpana Agrawal
发表日期
2019/6
期刊
Alcoholism: clinical and experimental research
卷号
43
期号
6
页码范围
1113-1125
简介
Background
Genomewide association studies (GWAS) have begun to identify loci related to alcohol consumption, but little is known about whether this genetic propensity overlaps with specific indices of problem drinking in ascertained samples.
Methods
In 6,731 European Americans who had been exposed to alcohol, we examined whether polygenic risk scores (PRS) from a GWAS of weekly alcohol consumption in the UK Biobank predicted variance in 6 alcohol‐related phenotypes: alcohol use, maximum drinks within 24 hours (MAXD), total score on the Self‐Rating of the Effects of Ethanol Questionnaire (SRE‐T), DSM‐IV alcohol dependence (DSM4AD), DSM‐5 alcohol use disorder symptom counts (DSM5AUDSX), and reduction/cessation of problematic drinking. We also examined the extent to which an single nucleotide polymorphism (rs1229984) in ADH1B, which is strongly associated with both alcohol …
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EC Johnson, CL St. Pierre, JL Meyers, F Aliev… - Alcoholism: clinical and experimental research, 2019