作者
Mihai Cristian Dumitrascu, Cristian Mares, Razvan-Cosmin Petca, Florica Sandru, Razvan-Ionut Popescu, Claudia Mehedintu, Aida Petca
发表日期
2020/12/1
来源
Oncology letters
卷号
20
期号
6
页码范围
1-1
出版商
Spandidos Publications
简介
Endocrine‑disrupting chemicals (EDCs) are exogenous chemical compounds ubiquitously found in everyday life of the modern world. EDCs enter the human body where they act similarly to endogenous hormones, altering the functions of the endocrine system and causing adverse effects on human health. Bisphenol A (BPA), the principal representative of this class, is a carbon‑based synthetic plastic, and a key element in manufacturing cans, reusable water bottles and medical equipment. BPA mimics the actions of estrogen on multiple levels by activating estrogen receptors α and β. BPA regulates various processes, such as cell proliferation, migration and apoptosis, leading to neoplastic changes. Considering genetic mechanisms, BPA exerts its functions via multiple oncogenic signaling pathways, including the STAT3, PI3K/AKT and MAPK pathways. Furthermore, BPA is associated with various modifications of …
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