查看文章

Objective. To evaluate the effect of metformin addition during ovarian hyperstimulation on cycle parameters and outcome of in vitro fertilization (IVF) treatment in polycystic ovary syndrome (PCOS) patients with a body mass index (BMI) <28 kg/m². Design. Retrospective review of patients’ records. Setting. Istanbul Memorial Hospital Assisted Reproductive Treatment Unit. Population. A total of 339 non-obese PCOS patients undergoing IVF were evaluated according to the supplementation of metformin. Methods. Cycle parameters and IVF outcomes of 220 patients given metformin were compared to those of 119 patients treated without metformin. Main outcome measures. Implantation and pregnancy rates. Results. Metformin co-treatment led to significantly lower peak E2 levels (3,481 pg/ml vs. 4,192 pg/ml; p <0.0001). However, gonadotropin consumption, stimulation duration, numbers of total and mature oocytes …