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Objective

Recently, the promising potential of fibroblast transplantation has become a novel modality for skin rejuvenation. We investigated the long-term safety and efficacy of autologous fibroblast transplantation for participants with mild to severe facial contour deformities.

Materials and Methods

In this open-label, single-arm phase IIa clinical trial, a total of 57 participants with wrinkles (n= 37, 132 treatment sites) or acne scars (n= 20, 36 treatment sites) who had an evaluator’s assessment score of at least 2 out 7 (based on a standard photo-guide scoring) received 3 injections of autologous cultured fibroblasts administered at 4-6 week intervals. Efficacy evaluations were performed at 2, 6, 12, and 24 months after the final injection based on evaluator and patient’s assessment scores.

Results

Our study showed a mean improvement of 2 scores in the wrinkle and acne scar treatment sites. At sixth months after …