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The finite element method (FEM) is a computational technique that is often used to solve biomedical engineering problems. The biphasic cartilage model plays important role in representing the mechanical behaviour of the articular cartilage. In order to obtain accurate results in finite element analysis of articular cartilage, it is necessary to determine appropriate FEM parameters such as mesh density and finite element type. Mode ls with small element sizes in the FEM allow more accurate re sul ts to be obtained however it requires longer calculation time. In contrast, large element size can lead to non-precision results while shortening the calculation time. The type of the elements may also change the results of FEM analysis for biomechanical problems. The purpose of this study is; to evaluate the effect of the mesh size and type of the finite element on the resul ts of the numerical biphasic tissues. In this study, in order to achieve thi s goal a series of compression analyzes were performed on the 3D biomedical models with different mesh density and element types using ABAQUS 6.13 software and the results were compared. The analysis results showed that mesh density element type and element type had little effect on the maximum reaction force. O n the contrary, the mesh density had greatly increased the computational time.