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Background: HPV infection is now established as a major etiologic factor for oropharyngeal cancer. E6 and E7 oncogenes of high risk HPV are known to stimulate angiogenesis by inducing the expression of Vascular Endothelial Growth Factor (VEGF). VEGF plays a central role in regulating angiogenesis and vasculogenesis in solid tumors and is tightly associated with the angiogenic switch. There is paucity of studies related to immunohistochemical expression of VEGF and its association with E6 and E7 oncoproteins of human papillomavirus in patients of oral and oropharyngeal carcinoma. Hence the purpose of this study is to find out and establish any correlation, if proven may be helpful in better management.

Methods: This study is a Hospital based descriptive observational cross sectional study conducted in the Department of Pathology in collaboration with Department of Otorhinolaryngology, Lady Hardinge …