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The goal of this research was to assess the effect of adding different percentages of copper oxide nanoparticles into soft denture lining materials on thermal conductance. The 30 samples were made of soft liner (The di-ameter is forty millimeters, while the thickness is 2.5 mm) were separated into (3) groups, Group (A) Control without adding Nano filler of (CuO)(10) specimens, Group (B) 0.3% CuO NPs addition (10) specimens, Group (C) 0.5% CuO NPs addition (10) specimens Each sample was measured with the thermal conductivity test machine (HOT DISK) to tested the thermal conductivity. The results showed Statistics that are descriptive for thermal conductivity for all experimental groups as shown in table (1) revealed that the mean value for 0.5% CuONPs groups was highest among all the groups (0.33±0.014), then Group (B) 0.3% CuO NPs. Then Group (A) Control without adding Nano filler.