作者
Karol Rawicz-Pruszyński, Yutaka Endo, Diamantis I Tsilimigras, Muhammad Musaab Munir, Vivian Resende, Alex Kim, Joal Beane, Zuzanna Pelc, Katarzyna Sędłak, Timothy M Pawlik
发表日期
2024/2
期刊
Annals of Surgical Oncology
卷号
31
期号
2
页码范围
753-761
出版商
Springer International Publishing
简介
Introduction
In the USA, approximately half of newly diagnosed patients with GC are 75 years or older. The objective of the current population-based study was to investigate the impact of neoadjuvant chemotherapy (NAC) on the outcomes of elderly patients with locally advanced GC.
Patients and Methods
Patients aged > 75 years were identified from the National Cancer Database (NCDB). The primary outcome of the study was overall survival (OS). Secondary outcomes included lymph node (LN) harvest, surgical margin status, and 30-day mortality. To minimize the effect of selection bias on the assessed outcome between the two study groups (NAC versus no NAC), propensity score matching (PSM) was performed.
Results
After PSM, a total of 1958 patients were included in both groups. NAC utilization increased from 2013 to 2019 (21% versus 42.7%, ptrend < 0.001). On pathologic analysis, patients who received …
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K Rawicz-Pruszyński, Y Endo, DI Tsilimigras, MM Munir… - Annals of Surgical Oncology, 2024