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It is common to observe a vector of discrete and/or continuous responses in scientific problems where the objective is to characterize the dependence of each response on explanatory variables and to account for the association between the outcomes. The response vector can comprise repeated observations on one variable, as in longitudinal studies or genetic studies of families, or can include observations for different variables. This paper discusses a class of models for the marginal expectations of each response and for pairwise associations. The marginal models are contrasted with log‐linear models. Two generalized estimating equation approaches are compared for parameter estimation. The first focuses on the regression parameters; the second simultaneously estimates the regression and association parameters. The robustness and efficiency of each is discussed. The methods are illustrated with …