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Adrenergic signaling plays critical roles in health and disease both peripherally and centrally. In the central nervous system, beta adrenergic receptors are broadly expressed and respond to norepinephrine (NE) signaling from neurons projected from the Locus Coeruleous (LC). NE is known to regulate attention, arousal, and acuity as well as fear learning in health and is implicated in neurodegenerative disease and post‐traumatic stress disorder (PTSD). Beta2 adrenergic receptors (B2ARs) are known to be involved in long term potentiation through Gs mediated activation of protein kinase A (PKA) which regulates calcium channels or through forming complexes with AMPA receptors. Recently published work from our lab has shown that functionally distinct and selectively phosphorylated subpopulations of B2ARs exist in a single neuron. These subpopulations of B2ARs are exclusively phosphorylated …