作者
Marc J Gunter, Donald R Hoover, Herbert Yu, Sylvia Wassertheil-Smoller, Thomas E Rohan, JoAnn E Manson, Jixin Li, Gloria YF Ho, Xiaonan Xue, Garnet L Anderson, Robert C Kaplan, Tiffany G Harris, Barbara V Howard, Judith Wylie-Rosett, Robert D Burk, Howard D Strickler
发表日期
2009/1/7
期刊
Journal of the National Cancer Institute
卷号
101
期号
1
页码范围
48-60
出版商
Oxford University Press
简介
Background
The positive association between obesity and postmenopausal breast cancer has been attributed, in part, to the fact that estrogen, a risk factor for breast cancer, is synthesized in adipose tissue. Obesity is also associated with high levels of insulin, a known mitogen. However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of estrogen level.
Methods
We conducted a case–cohort study of incident breast cancer among nondiabetic women who were enrolled in the Women's Health Initiative Observational Study (WHI-OS), a prospective cohort of 93 676 postmenopausal women. Fasting serum samples obtained at study entry from 835 incident breast cancer case subjects and from a subcohort of 816 randomly chosen …
引用总数
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MJ Gunter, DR Hoover, H Yu, S Wassertheil-Smoller… - Journal of the National Cancer Institute, 2009