作者
Nathalie L Jansen, Vera Graute, Lena Armbruster, Bogdana Suchorska, Juergen Lutz, Sabina Eigenbrod, Paul Cumming, Peter Bartenstein, Jörg-Christian Tonn, Friedrich Wilhelm Kreth, Christian La Fougère
发表日期
2012/6
期刊
European journal of nuclear medicine and molecular imaging
卷号
39
页码范围
1021-1029
出版商
Springer-Verlag
简介
Purpose
Since differentiation between low-grade glioma (LGG) and high-grade glioma (HGG) remains challenging according to MRI criteria alone, we investigated the discriminative value of additional dynamic FET PET in patients with MRI-suspected LGG.
Methods
Included in this retrospective study were 127 patients with newly diagnosed MRI-suspected LGG and dynamic FET PET prior to histopathological assessment. FET PET lesions were visually classified as having reduced, normal, or increased tracer uptake. Maximal tumour uptake scaled to the mean background uptake (SUVmax/BG), mean tumour uptake (SUVmean/BG), biological tumour volume and kinetics were evaluated and correlated with individual histopathological findings.
Results
Histopathological analysis revealed 71 patients with LGG, 47 patients …
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