作者
Nathalie L Jansen, Christoph Schwartz, Vera Graute, Sabina Eigenbrod, Jürgen Lutz, Rupert Egensperger, Gabriele Pöpperl, Hans A Kretzschmar, Paul Cumming, Peter Bartenstein, Jörg-Christian Tonn, Friedrich-Wilhelm Kreth, Christian la Fougère, Niklas Thon
发表日期
2012/12/1
期刊
Neuro-oncology
卷号
14
期号
12
页码范围
1473-1480
出版商
Oxford University Press
简介
Oligodendroglial components (OC) and loss of heterozygosity on chromosomes 1p and 19q (LOH 1p/19q) are associated with better outcome in patients with glioma. We aimed to assess the fitness of [18F]fluoroethyltyrosine positron-emission-tomography (FET-PET) for noninvasively identifying these important prognostic/predictive factors. One hundred forty-four patients with MRI-suspected WHO grade II and III glioma underwent FET-PET scans prior to histological diagnosis. FET-PET analyses included maximal tumoral uptake (SUVmax/BG), biological tumor volume (BTV), mean tumoral uptake (SUVmean/BG), total tumoral uptake (SUVtotal/BG), and kinetic analysis. Suspicion of OC was based on static and dynamic FET-uptake parameters. PET results were correlated with histology and 1p/19q status. OC tumors exhibited significantly higher uptake values, compared with astrocytomas (AC) (SUVmax/BG 3.1 …
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NL Jansen, C Schwartz, V Graute, S Eigenbrod, J Lutz… - Neuro-oncology, 2012