作者
Donghyun Lee, Wan-Kyu Ko, Deok-Sang Hwang, Dong Nyoung Heo, Sang Jin Lee, Min Heo, Kook-Sun Lee, Ji-Yoon Ahn, Junyoung Jo, Il Keun Kwon
发表日期
2016/12
期刊
Nanoscale research letters
卷号
11
页码范围
1-6
出版商
Springer US
简介
Baicalin (BC) has been used for cancer therapy due to its multiple effects as an anti-cancer drug. However, the effective delivery of this molecule to targeted cells is difficult. Gold nanoparticles (AuNPs) conjugated with thiolated beta cyclodextrin (AuNP-S-β-CD) were used as a delivery vector in this study. Cell viability tests were evaluated by cell counting kit-8 (CCK) and live/dead cell assay. To demonstrate the proliferation inhibition effect on Michigan Cancer Foundation-7 (MCF-7) cells by BC, we analyzed using Hoechst 33342 staining assay and gel electrophoresis. The S-β-CD conjugated AuNPs were characterized by transmission electron microscopy (TEM), 1H nuclear magnetic resonance (1H NMR), and ultraviolet visible (UV-vis) spectroscopy. AuNP-S-β-CD with approximately 40 μM of BC loaded by inclusion complex showed an inhibition effect on MCF-7 cells by inducing apoptosis. Apoptosis test …
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D Lee, WK Ko, DS Hwang, DN Heo, SJ Lee, M Heo… - Nanoscale research letters, 2016