作者
F Mindlen, R Nordaby, M Ruiz, A Zavala, L Guzman, F Martinez, RR Diaz, C Mackey, M Marino, G Romero, G Zapata, C Cuneo, T Kawamura, O Coelho, O Massayochi, J Braga, A Labrunie, L Bodanese, E Manenti, D Vitola, J Nicolau, C Amodeo, D Armaganijan, M Bertolami, B Caramelli, A Carvalho, C Cirenza, M Fichino, R Franken, N Ghorayeb, T Kadri, P Leao, F Malheiros, R Pavanello, F Ramires, J Ramires, F Savioli, A Sousa, L Tanajura, D Topps, L Korner, B Baptie, M Basinger, B Baylis, P Beresford, A Edwards, P Giannaccaro, Y Groenewoud, M Grose, J Kellen, S Lam, R Lesoway, P Ma, D Meldrum, D Mitchell, LB Mitchell, D Roth, S Shumak, M Simon, J Stone, W Warnica, D Wyse, C Neffgen, J Neffgen, F Armstrong, W Armstrong, N Bell, W Black, N Brass, F Brenneis, R Brownoff, G Chaytors, D DeBanne, C Derksen, M Donoff, M Goeres, P Greenwood, S Gulamhusein, W Hui, K Hutchison, L Kasian, L Kasza, E Krikke, L Kvill, Z Lakhani, D Linklater, J Mackel, S Martin, T Montague, D Moores, A Musseau, T Muzyka, J Paradis, A Prosser, E Ryan, M Senaratne, P Stenerson, T Talibi, K Teo, C Young, R White, K Browne, M Browne, K Happel, A Irving, A Plesko, R Donnelly, N Radomsky, P Felker, D Larsen, J Morse, C Rowntree, J Thompson, R Wedel, G Bloomberg, G Chomin, M Dahl, W Leong, J Heath, J Marshall, M Terwiel, G Kenefick, R Kuritzky, K Stevens, K Weddings, K Barban, J Imrie, K Woo, T Ashton, K Calvert, W Bishop, R Sweeney, L Breakwell, J Kornder, S Pearce, P Polasek, P Richardson, S Ghosh, M Rielly, K Wagner, K Dawson, P Lee, J Lewis, K MacDonald, L McGee, C Thompson, D Hilton, K Illott, P Klinke, J McConnell
发表日期
1996/2/1
期刊
Canadian Journal of Cardiology
卷号
12
期号
2
页码范围
127-137
出版商
ELSEVIER SCIENCE INC
简介
OBJECTIVE
To describe the design of the HOPE (Heart Outcomes Prevention Evaluation) Study.
DESIGN
Description of the key design features of HOPE, a large, simple randomized trial of two widely applicable treatments - ramipril, an angiotensin-converting enzyme inhibitor; and vitamin E, a naturally occurring antioxidant vitamin - in the prevention of myocardial infarction, stroke or cardiovascular death.
SETTING
Two-hundred and sixty-seven hospitals, physician offices and clinics in Canada, the United States, Mexico, Europe and South America.
PATIENTS
Over 9000 women and men aged 55 years and above at high risk for cardiovascular events such as myocardial infarction and stroke were recruited over 18 months.
INTERVENTIONS
A 2x2 factorial design with ramipril and vitamin E with follow-up for up to four years.
CONCLUSIONS
HOPE will be one of the largest trials of two new interventions to prevent …
引用总数
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F Mindlen, R Nordaby, M Ruiz, A Zavala, L Guzman… - Canadian Journal of Cardiology, 1996
