作者
John T O'Brien, Sean Colloby, John Fenwick, E David Williams, Michael Firbank, David Burn, Dag Aarsland, Ian G McKeith
发表日期
2004/6/1
期刊
Archives of neurology
卷号
61
期号
6
页码范围
919-925
出版商
American Medical Association
简介
Background
Dementia with Lewy bodies (DLB) is a common form of late-life dementia that can be difficult to differentiate from other disorders, especially Alzheimer disease (AD), during life. At autopsy the striatal dopaminergic transporter is reduced.
Objectives
To examine the extent and pattern of dopamine transporter loss using iodine I 123–radiolabeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (FP-CIT) with single-photon emission computed tomography (SPECT) in DLBs compared with other dementias and to assess its potential to enhance a differential diagnosis.
Design
Cohort study comparing FP-CIT with criterion standard of consensus clinical diagnosis.
Setting
General hospital.
Participants
One hundred sixty-four older subjects (33 healthy older control subjects, 34 with NINCDS/ADRDA [National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer's Disease …
引用总数
学术搜索中的文章
JT O'Brien, S Colloby, J Fenwick, ED Williams… - Archives of neurology, 2004
