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Diabetes is a multisystem disorder and its effects are observed on the reproductive system. One of the main causes of testicular tissue damage is diabetes-induced overproduction of reactive oxygen species and glycated end products. The main objectives of this study were to investigate the possible effects of agomelatine (AG) and gallic acid (GA) in suppressing oxidative stress in Type I diabetes induced testicular damage. A total of 28 adult male rats were included in the study. Diabetes was induced by intraperitoneal injection of streptozocin (STZ, 55 mg/kg) to 21 rats, which were then randomly assigned to 3 groups; 1 mL saline solution was given to the diabetes + saline group by oral gavage, 20 mg/kg/day oral AG was given to the diabetes + AG group, and 20 mg/kg/day oral GA was given to the diabetes + GA group for 4 weeks. Tumor necrosis factor α (TNFα), nitric oxide synthase 2 (NOS2), fibronectin and …