作者
Masafumi Goto, Tatsuya Takahashi, Fumiko Yamashita, Ako Koreeda, Hiromasa Mori, Michio Ohta, Yoshichika Arakawa
发表日期
1997/11/15
期刊
Biological and Pharmaceutical Bulletin
卷号
20
期号
11
页码范围
1136-1140
出版商
The Pharmaceutical Society of Japan
简介
Low molecular weight thiol compounds have been found to be strong inhibitors of metallo-β-lactamase (IMP-1) produced by Serratia marcescens TN9106, which was expressed by Echerichia coli JM109 cells. Mercaptoacetic acid and 2-mercaptopropionic acid strongly and competitively inhibited IMP-1 with K i of 0.23 and 0.19 μM, respectively. 2-Mercaptoethanol reversibly inhibited IMP-1 but did not show simple competitive inhibition.
引用总数
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M Goto, T Takahashi, F Yamashita, A Koreeda, H Mori… - Biological and Pharmaceutical Bulletin, 1997