作者
Alma Villasenor, James M Kinross, Jia V Li, Nicholas Penney, Richard H Barton, Jeremy K Nicholson, Ara Darzi, Coral Barbas, Elaine Holmes
发表日期
2014/12/5
期刊
Journal of proteome research
卷号
13
期号
12
页码范围
5362-5375
出版商
American Chemical Society
简介
We have investigated the urinary and plasma metabolic phenotype of acute pancreatitis (AP) patients presenting to the emergency room at a single center London teaching hospital with acute abdominal pain using 1H NMR spectroscopy and multivariate modeling. Patients were allocated to either the AP (n = 15) or non-AP patients group (all other causes of abdominal pain, n = 21) on the basis of the national guidelines. Patients were assessed for three clinical outcomes: (1) diagnosis of AP, (2) etiology of AP caused by alcohol consumption and cholelithiasis, and (3) AP severity based on the Glasgow score. Samples from AP patients were characterized by high levels of urinary ketone bodies, glucose, plasma choline and lipid, and relatively low levels of urinary hippurate, creatine and plasma-branched chain amino acids. AP could be reliably identified with a high degree of sensitivity and specificity (OPLS-DA …
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A Villasenor, JM Kinross, JV Li, N Penney, RH Barton… - Journal of proteome research, 2014