作者
Shan Yu, Lin Jia, Yan Zhang, Dinglan Wu, Zhenyu Xu, Chi-Fai Ng, Kenneth KW To, Yu Huang, Franky L Chan
发表日期
2013/1/1
期刊
Cancer letters
卷号
328
期号
1
页码范围
83-94
出版商
Elsevier
简介
Development of antiandrogen-resistance in advanced prostate cancer involves multiple androgen receptor (AR)-dependent and -independent pathways. Here, we demonstrated that endothelial nitric oxide synthase (eNOS) exhibited an overexpression pattern in hormone-refractory prostate cancer and several models of advanced hormone-resistant prostate cancer. We further established a novel in vitro model of antiandrogen-resistant prostate cancer (LNCaP-BC) by long-term bicalutamide treatment. Besides antiandrogen-resistant and other enhanced malignant growth phenotypes, LNCaP-BC cells exhibited an increased activated eNOS expression and NO production, and suppressed AR transactivation status. Treatment with a NOS inhibitor L-NAME could re-sensitize the growth response to bicalutamide and enhance the AR transactivation in LNCaP-BC cells. Together, our present findings indicate that …
学术搜索中的文章
S Yu, L Jia, Y Zhang, D Wu, Z Xu, CF Ng, KKW To… - Cancer letters, 2013