作者
Houpu Li, Hsin‐ya Yang, Narges Asefifeyzabadi, Prabhat Baniya, Andrea Medina Lopez, Anthony Gallegos, Kan Zhu, Tiffany Nguyen, Cristian Hernandez, Ksenia Zlobina, Cynthia Recendez, Hao‐Chieh Hsieh, Maryam Tebyani, Héctor Carrión, John Selberg, Le Luo, Moyasar A Alhamo, Alexie Barbee, Jonathan Orozco, Cathleen Hsieh, Athena M Soulika, Michael Levin, Narges Norouzi, Marcella Gomez, Min Zhao, Mircea Teodorescu, Roslyn Rivkah Isseroff, Marco Rolandi
发表日期
2024/4
期刊
Advanced Materials Technologies
卷号
9
期号
7
页码范围
2301115
简介
The ability to deliver drugs with precise dosages at specific time points can significantly improve disease treatment while reducing side effects. Drug encapsulation for gradual delivery has opened the doors for a superior treatment regimen. To expand on this ability, programming bioelectronic devices to deliver small molecules enables ad‐hoc personalized therapeutic profiles that are more complex than gradual release. Here, a wearable bioelectronic device with an integrated electrophoretic ion pump that affords on‐demand drug delivery with precise dose control is introduced. Delivery of fluoxetine to wounds in mice result in a 27.2% decrease in the macrophage ratio (M1/M2) and a 39.9% increase in re‐epithelialization, indicating a shorter inflammatory phase and faster overall healing. Programmable drug delivery using wearable bioelectronics in wounds introduces a broadly applicable strategy for the long …
学术搜索中的文章
H Li, H Yang, N Asefifeyzabadi, P Baniya, AM Lopez… - Advanced Materials Technologies, 2024