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Current evidence on associations between intakes of linoleic acid (LA), the predominant n–6 (ω-6) fatty acid, and mortality is inconsistent and has not been summarized by a systematic review and meta-analysis.

The aim was to perform a systematic review and meta-analysis of prospective cohort studies to examine associations between LA intake and mortality.

We conducted a comprehensive search of MEDLINE and EMBASE databases through 31 July 2019 for prospective cohort studies reporting associations of LA (assessed by dietary surveys and/or LA concentrations in adipose tissue or blood compartments) with mortality from all causes, cardiovascular disease (CVD), and cancer. Multivariable-adjusted RRs were pooled using random-effects meta-analysis.

Thirty-eight studies reporting 44 prospective cohorts were identified; these included 811,069 participants with dietary …