作者
Merwan Ginet, Timothée Zaragori, Pierre-Yves Marie, Véronique Roch, Guillaume Gauchotte, Fabien Rech, Marie Blonski, Zohra Lamiral, Luc Taillandier, Laëtitia Imbert, Antoine Verger
发表日期
2020/6
期刊
European journal of nuclear medicine and molecular imaging
卷号
47
页码范围
1381-1390
出版商
Springer Berlin Heidelberg
简介
Purpose
18F-FDopa PET imaging of gliomas is routinely interpreted with standardized uptake value (SUV)-derived indices. This study aimed to determine the added value of dynamic 18F-FDopa PET parameters for predicting the molecular features of newly diagnosed gliomas.
Methods
We retrospectively included 58 patients having undergone an 18F-FDopa PET for establishing the initial diagnosis of gliomas, whose molecular features were additionally characterized according to the WHO 2016 classification. Dynamic parameters, involving time-to-peak (TTP) values and curve slopes, were tested for the prediction of glioma types in addition to current static parameters, i.e., tumor-to-normal brain or tumor-to-striatum SUV ratios and metabolic tumor volume (MTV).
Results
There were 21 IDH mutant without 1p/19q co-deletion (IDH+/1p19q−) gliomas, 16 IDH mutants with 1p/19q co-deletion (IDH+/1p19q …
学术搜索中的文章
M Ginet, T Zaragori, PY Marie, V Roch, G Gauchotte… - European journal of nuclear medicine and molecular …, 2020