作者
JF Bermejo‐Martín, A Rodriguez‐Fernandez, Rubén Herrán‐Monge, D Andaluz‐Ojeda, A Muriel‐Bombín, P Merino, MM García‐García, R Citores, F Gandía, R Almansa, J Blanco, GRECIA Group (Grupo de Estudios y Análisis en Cuidados Intensivos)
发表日期
2014/10
期刊
Journal of internal medicine
卷号
276
期号
4
页码范围
404-412
简介
Objective
The impact of endogenous immunoglobulin isotypes on the prognosis of patients with severe sepsis has not been sufficiently explored. The aim of this study was to evaluate the association between immunoglobulin levels in plasma and survival in patients with this condition.
Design and patients
A prospective multicentre cohort study was conducted. A total of 172 adult patients admitted to the intensive care unit (ICU) with severe sepsis or septic shock were recruited. Patients were classified based on deciles of immunoglobulin concentrations at diagnosis of sepsis. Categorical variables were created and tested for their association with survival during hospitalization in the ICU.
Results
Overall, 42 patients died in the ICU during the study. Kaplan–Meier analysis showed that immunoglobulin concentrations below 300 mg dL−1 for IgG1, 35 mg dL−1 for IgM and 150 mg dL−1 for IgA were associated with …
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