作者
Jesús Villar, Rosa L Fernández, Alfonso Ambrós, Laura Parra, Jesús Blanco, Ana M Domínguez-Berrot, José M Gutiérrez, Lluís Blanch, José M Añón, Carmen Martín, Francisca Prieto, Javier Collado, Lina Pérez-Méndez, Robert M Kacmarek, Acute Lung Injury: Epidemiology and Natural history (ALIEN) Network
发表日期
2015/2/1
期刊
Critical care medicine
卷号
43
期号
2
页码范围
346-353
出版商
LWW
简介
Objective: Current in-hospital mortality of the acute respiratory distress syndrome (ARDS) is above 40%. ARDS outcome depends on the lung injury severity within the first 24 hours of ARDS onset. We investigated whether two widely accepted cutoff values of PaO 2/FIO 2 and positive end-expiratory pressure (PEEP) would identify subsets of patients with ARDS for predicting outcome and guiding therapy.
Design: A 16-month (September 2008 to January 2010) prospective, multicenter, observational study.
Setting: Seventeen multidisciplinary ICUs in Spain.
Patients: We studied 300 consecutive, mechanically ventilated patients meeting American-European Consensus Conference criteria for ARDS (PaO 2/FIO 2≤ 200 mm Hg) on PEEP greater than or equal to 5 cm H 2 O, and followed up until hospital discharge.
Interventions: None.
Measurements and Main Results: Based on threshold values for PaO 2/FIO 2 (150 mm …
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J Villar, RL Fernández, A Ambrós, L Parra, J Blanco… - Critical care medicine, 2015