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OBJECTIVE: To reevaluate ovarian hyperstimulation syndrome (OHSS) prevention techniques and provide a classification system for grading OHSS and evidence-based treatment strategies for preventing OHSS. DESIGN: A literature search was conducted in PubMed for articles published in the last 5 years using the keywords “controlled ovarian stimulation,” “controlled ovarian hyperstimulation,” “ovarian hyperstimulation syndrome,” “OHSS,” “prevention,” “chorionic gonadotropin,” “hCG,” “GnRH agonist,” “GnRH antagonist,” “coasting,” and “cryopreservation.” We reviewed randomized controlled trials (RCTs), retrospective studies, pilot studies, case studies, reviews, and meta-analyses. RESULT(S): There is a shortage of large, prospective RCTs reporting OHSS prediction and prevention strategies. Our review showed that risk factors such as antral follicle count and baseline anti-Müllerian hormone level may …