查看文章

The objective of the present study was to formulate naproxen–eudragit^® RS100 nanoparticles and investigate the physicochemical characteristics of the prepared nanoparticles. The nanoparticles of naproxen with eudragit^® RS100 were formulated using the solvent evaporation/extraction technique (the single emulsion technique). The effect of several process parameters, i.e., drug/polymer ratio, aqueous phase volume and speed of homogenization were considered on the size of the nanoformulations. The physicochemical characteristics of nanoparticles were studied applying particle size analysis, differential scanning calorimetry, X-ray crystallography, Fourier transform infrared spectroscopy and scanning electron microscopy. The release rate of naproxen from various drug/polymer nanoparticles was investigated as well. All the prepared formulations using eudragit^® RS100 resulted in nano-range size particles …